ARP4193-61
[Polyclonal Antibody]
MDM2 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IHC IF ICC |
| Immunogen Range: | A synthetic peptide derived from human MDM2 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 4193 |
| Swiss Prot: | Q00987 |
| Synonyms: | Double minute 2 protein, double minute 2, human homolog of, E3 ubiquitin-protein ligase Mdm2, Hdm2, HDMX, MDM2, Mdm2 p53 binding protein homolog (mouse), Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, MGC71221, Oncoprotein Mdm2 |
| Purification: | Affinity chromatography |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | MDM2 a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 via Akt-mediated MDM2 phosphorylation. Phosphorylation of MDM2 increases its interaction with p300, providing a platform to allow the assembly of the protein complex necessary for MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53. Facilitates the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Eight alternatively spliced isoforms have been reported. |
| Caculated MW: | 90 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:3000 IHC 1:50-1:200 IF 1:100-1:500 ICC 1:100-1:500 |
| Reacitivity: | Human, Mouse, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
