ARP2261-61 [Polyclonal Antibody]
FGFR3 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic peptide derived from human FGFR3
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   2261
Swiss Prot:   P22607
Synonyms:   ACH, achondroplasia, thanatophoric dwarfism, CD333, CEK2, FGFR-3, FGFR3, Fibroblast growth factor receptor 3, HSFGFR3EX, hydroxyaryl-protein kinase, JTK4, tyrosine kinase JTK4
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   FGFR3 a receptor tyrosine kinase of the highly-conserved FGFR family that binds fibroblast growth factor (FGF). Mutations are associated with thanatophoric dysplasia (TD), craniosynostosis Adelaide type, many craniosynostotic syndromes and bone malformations. Three splice-variant isoforms have been described. Activating point mutations cause dwarfism, including achondroplasia, hypochrondroplasia and thanatophoric dysplasia, and facial and other morphogenetic disorders, including Crouzon syndrome, craniosynostosis Adelaide type, San Diego skeletal displasia and Muenke syndrome. Translocations t(4;14) involving the IgH region are common in multiple myeloma and frequently involve FGFR3.
Caculated MW:   95 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:3000
IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information