ARP10018-61 [Polyclonal Antibody]
BIM Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic peptide derived from human BIM
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   10018
Swiss Prot:   O43521
Synonyms:   B2L11, BAM, bcl-2 interacting mediator of cell death, bcl-2 interacting protein Bim, Bcl-2-like protein 11, bcl-2-related ovarian death agonist, Bcl2-interacting mediator of cell death, Bcl2-L-11, BCL2-like 11 (apoptosis facilitator), BCL2L11, BIM, BIM-a
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Bim a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Eight alternatively spliced transcript variants of this gene have been reported.
Caculated MW:   22,25 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:3000
IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information