ARP200558-61 [Polyclonal Antibody]
APLF Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic peptide derived from human APLF
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   200558
Swiss Prot:   Q8IW19
Synonyms:   APFL, APLF, Aprataxin and PNK-like factor, aprataxin and PNKP like factor, aprataxin- and PNK-like factor, Apurinic-apyrimidinic endonuclease APLF, C2orf13, FLJ16593, MGC47799, PALF, PNK and APTX-like FHA domain-containing protein, PNK and APTX-like FHA p
Purification:   Affinity chromatography
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   APLF Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Belongs to the APLF family. Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5.
Caculated MW:   57 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:3000
IHC 1:50-1:200
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information