Species: | Rabbit |
Applications: | WB IHC IF ICC |
Immunogen Range: | A synthetic peptide derived from human CD227/MUC1 around the phosphorylation site of Tyrosine 1229 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 4582 |
Swiss Prot: | P15941 |
Synonyms: | Breast carcinoma-associated antigen DF3, CD227, Carcinoma-associated mucin, EMA, Episialin, H23AG, MUC-1, MUC1, Mucin 1 precursor, PEM, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, T |
Purification: | Affinity purification |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. This protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. The protein serves a protective function, binding to pathogens, as well as functioning in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Caculated MW: | 170 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:100-1:500 ICC 1:100-1:500 |
Reacitivity: | Human |