ARP5170P-01 [Polyclonal Antibody]
Phospho-PDPK1-Ser241 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   A phospho specific peptide corresponding to residues surrounding S241 of human PDPK1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   5170
Swiss Prot:   O15530
Synonyms:   PDK1, PDPK2, PRO0461
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The μ-opioid receptor (MOR) belongs to the superfamily of G-protein-coupled receptors. MOR mediates the analgesic and rewarding effects of morphine and other opiates as well as the actions of several endogenous opioid peptides. Upon binding to its ligands, this Gi-coupled receptor inactivates adenylyl cyclase and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Trafficking of these receptors to and from the plasma membrane and their desensitization play a significant role in morphine tolerance. As with other GPCRs, these processes are modulated by phosphorylation at diverse sites within intracellular domains. Among other sites, agonist-specific phosphorylation of serine 375 in mouse (serine 377 in human) MOR is essential for its internalization.
Caculated MW:   63 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
IHC 1:50-1:100
IF 1:100-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information