
| Species: | Rabbit |
| Applications: | WB IHC IF |
| Immunogen Range: | A phospho specific peptide corresponding to residues surrounding S51 of human EIF2S1 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 1965 |
| Swiss Prot: | P05198 |
| Synonyms: | EIF2, EIF-2, EIF2A, EIF-2A, EIF-2alpha |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S28), and the 52-kD EIF2-gamma subunit (EIF2S3). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha. |
| Caculated MW: | 38 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:2000 IHC 1:50-1:100 IF 1:100-1:200 |
| Reacitivity: | Human, Mouse, Rat |