Species: | Rabbit |
Applications: | WB IHC IF |
Immunogen Range: | A phospho specific peptide corresponding to residues surrounding S3 of human CFL1 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 1072 |
Swiss Prot: | P23528 |
Synonyms: | CFL, CFL1, p18, Cofilin 1 |
Purification: | Affinity purification |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. |
Caculated MW: | 19 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:50-1:100 IF 1:100-1:200 |
Reacitivity: | Human, Mouse, Rat |