ARP673P-11 [Polyclonal Antibody]
Phospho-BRAF-Ser445 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   ELISA Dot
Immunogen Range:   A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S445 of human BRAF
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   673
Swiss Prot:   P15056
Synonyms:   B-RAF1, BRAF1, FLJ95109, MGC126806, MGC138284, RAFB1
Purification:   Protein A purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
Caculated MW:   86 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information