Species: | Rabbit |
Applications: | WB IHC IF |
Immunogen Range: | A recombinant protein of human NDE1 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 54820 |
Swiss Prot: | Q9NXR1 |
Synonyms: | NDE, LIS4, MHAC, NUDE, NUDE1, HOM-TES-87 |
Purification: | Affinity purification |
Storage: | Store at -20oC (regular) or -80oC (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background: | This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. |
Caculated MW: | 39kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:100 |
Reacitivity: | Human, Mouse |