ARP1729-02 [Polyclonal Antibody]
DIAPH1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A recombinant protein of human DIAPH1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   1729
Swiss Prot:   O60610
Synonyms:   DIA1, DRF1, DFNA1, LFHL1, hDIA1
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Formins are a family of large multidomain actin nucleation/polymerization proteins characterized by their catalytic FH2 domains. The mammalian diaphanous-related formin (mDia/diap) subfamily, including mDia1/diap1, mDia2/diap3 and mDia3/diap2, are effectors of Rho family small GTPases. In response to Rho, mDia/diap proteins are involved in the regulation of multiple cell functions including cytoskeletal dynamics, migration, adhesion, polarity and cell shape. mDia1/diap1 is activated by GTP-bound Rho, leading to Rho-associated kinase (ROCK)-dependent stress fiber formation. Rho activation of mDia1 has also been shown to regulate serum response factor (SRF)-dependent transcription, and has been implicated in human cancer phenotypes such as ras-mediated transformation, metastasis and invasion. mDia3/diap2, activated by the Rho family small GTPase cdc42, regulates the attachment of microtubules to the kinetochore during mitosis in mammalian cells. Rho-dependent activation of mDia2/diap3 is important in assembly of the contractile ring during cytokinesis.
Caculated MW:   141 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information