ARP54556-01 [Polyclonal Antibody]
ING3 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IP IF
Immunogen Range:   A recombinant protein of human ING3
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   54556
Swiss Prot:   Q9NXR8
Synonyms:   Eaf4, ING2, MEAF4, p47ING3
Purification:   Affinity purification
Storage:   Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background:   The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Caculated MW:   46kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50- 1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information