
| Species: | Rabbit |
| Applications: | WB IHC IF |
| Immunogen Range: | A recombinant protein of human RAD18 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 56852 |
| Swiss Prot: | Q9NS91 |
| Synonyms: | RNF73 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. |
| Caculated MW: | 56 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:2000 IHC 1:50-1:20 IF 1:50-1:200 |
| Reacitivity: | Human, Mouse, Rat |