ARP5864-11 [Polyclonal Antibody]
RAB3A Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC IF
Immunogen Range:   A recombinant protein corresponding to amino acids of human RAB3A
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   5864
Swiss Prot:   P20336
Synonyms:   /
Purification:   Antigen affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS with 0.02% sodium azide and 40% glycerol. Avoid freeze/thaw cycles.
Background:   The Rab family of proteins includes small, monomeric GTPases essential for regulating intracellular vesicle trafficking. Members of the Rab3 subfamily, including Rab3A-3D, are involved in the exocytosis of neurotransmitters and hormones. Rab3A is primarily expressed in neurons, neuroendocrine cells (such as rat PC-12 cells), and in human pancreatic β cells. By acting as a molecular switch between active GTP-bound Rab3A and the inactive GDP-bound form, Rab3A inhibits synaptic vesicle and chromaffin granule secretion during late membrane release. Loss-of-function studies suggest Rab3A is involved in controlling synaptic vesicle targeting and docking at the active zone. Through binding to its direct effector Rabphillin, Rab3A also orchestrates the coupling between synaptic vesicle exocytosis and endocytosis.
Caculated MW:   25 kDa
Observed MW:   Refer to Figures
Applications:   IF 1-4 ug/ml
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information