ARP3399-11 [Polyclonal Antibody]
ID3 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC
Immunogen Range:   A synthetic peptide corresponding to C-terminus of human ID3
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   3399
Swiss Prot:   Q02535
Synonyms:   HEIR-1, bHLHb25
Purification:   Affinity purification
Storage:   Store at -20°C or lower in PBS(pH 7.4). Avoid freeze/thaw cycles.
Background:   Inhibitor of DNA-binding/Differentiation (ID) proteins are a family of proteins that function to repress the activity of basic helix-loop-helix (bHLH) transcription factors. There are four known ID proteins in humans (ID1-4), all of which contain a helix-loop-helix domain but lack a basic DNA binding domain. Heterodimerization with bHLH transcription factors therefore functions to sequester bHLH proteins and prevent their binding to DNA. ID proteins play important functional roles in development, primarily by inhibiting premature differentiation of stem/progenitor cells. ID3 plays an important role in immune system development where it has been shown to repress E2A-mediated differentiation of T cells. Studies in mouse models have shown that homozygous deletion of ID3 disrupts regulatory T cell differentiation and leads to development of γδ T cell lymphoma. Outside of the hematopoietic compartment, ID3 was shown to repress MyoD, implicating 3 in TGFβ-mediated muscle repair. Similarly, research studies have shown that ID3 suppresses p21 in colon cancer cells, a function that is purported to promote the self-renewal capacity of putative cancer-initiating cells.
Caculated MW:   13 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information