Species: | Rabbit |
Applications: | WB IHC IF |
Immunogen Range: | A recombinant protein of human GFRA1 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 2674 |
Swiss Prot: | P56159 |
Synonyms: | GDNFR, RET1L, RETL1, TRNR1, GDNFRA, GFR-ALPHA-1 |
Purification: | Affinity purification |
Storage: | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background: | Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. |
Caculated MW: | 51kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reacitivity: | Human, Mouse, Rat |