ARP55677-01 [Polyclonal Antibody]
IWS1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A recombinant protein of human IWS1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   55677
Swiss Prot:   Q96ST2
Synonyms:   DKFZp761G0123, FLJ10006, FLJ14655, FLJ32319, MGC126375, MGC126376
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Various steps in gene expression, such as mRNA processing, surveillance, export, and synthesis are coupled to transcription elongation. The C-terminal domain (CTD) of the large subunit of RNA polymerase II plays an important role in the integration of these different steps. IWS1 interacts with Spt6, a CTD-binding transcription elongation factor and H3 chaperone. IWS1 also recruits another CTD-binding protein, HYPB/Setd2 histone methyltransferase, to the RNA polymerase II complex for elongation-coupled H3K36 trimethylation. Thus, IWS1 links Spt6 and HYPB/Setd2 in a large complex and regulates mRNA synthesis and histone methylation at the co-transcriptional level.
Caculated MW:   92 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information