ARP7316-01
[Polyclonal Antibody]
Ubiquitin Rabbit Polyclonal Antibody
www.yhsbio.com
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support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IHC ICC FC |
| Immunogen Range: | A synthetic peptide of human Ubiquitin C |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 7316 |
| Swiss Prot: | P0CG48 |
| Synonyms: | UBC, HMG20, Ubiquitin |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the ubiquitin-activating enzyme (UBE1 or E1). The activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, and then from E2 to ubiquitin ligase E3 for final delivery to the ε-amino group of the target protein lysine residue (1-3). Combinatorial interactions of different E2 and E3 proteins result in substrate specificity (4). UBE1 has two isofoms: UBE1a is a nuclear protein of 117 kDa while UBE1b is a nuclear and cytoplasmic protein of 110 kDa (5). |
| Caculated MW: | 8 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:1000-1:2000 IHC 1:100-1:200 ICC 1:100-1:200 FC 1:50-1:200 |
| Reacitivity: | Human, Mouse, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
