Species: | Rabbit |
Applications: | WB IHC IF |
Immunogen Range: | A recombinant protein of human HNMT |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 3176 |
Swiss Prot: | P50135 |
Synonyms: | HMT, HNMT-S1, HNMT-S2 |
Purification: | Affinity purification |
Storage: | Store at -20oC (regular) or -80oC (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background: | In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. |
Caculated MW: | 33kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reacitivity: | Human, Mouse, Rat |