ARP26353-11 [Polyclonal Antibody]
HSPB8 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IP IF
Immunogen Range:   Human HSPB8
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   26353
Swiss Prot:   Q9UJY1
Synonyms:   CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22
Purification:   Affinity purification
Storage:   Store at -20°C or lower in antiserum. Avoid freeze/thaw cycles.
Background:   HSPB8 (HSP22) is a member of the small heat shock protein superfamily and the human protein is most closely related to HSP27. Similar to most other small HSPs (sHSPs), HSPB8 is predominantly transcribed in skeletal muscle and heart (1). In a two hybrid screen, HSPB8 interacted preferentially with a triple aspartate form of HSP27 which mimics HSP27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type HSP27 (2). HSPB8 has two binding domains (N- and C-terminal) that are specific for different binding partners, and has the ability to bind to itself and other sHSPs such as HSPB7 and HSPB2 (3). The chaperone-like activity is of great importance to the function of HSP22 in various processes including proliferation, apoptosis and macroautophagy (4).
Caculated MW:   22 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information