ARP56254-01 [Polyclonal Antibody]
RNF20 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IF IP
Immunogen Range:   A recombinant protein of human RNF20
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   56254
Swiss Prot:   Q5VTR2
Synonyms:   BRE1, BRE1A, hBRE1
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Caculated MW:   114 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000-1:2000
IF 1:50-1:100
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information