Species: | Rabbit |
Applications: | WB IHC ICC |
Immunogen Range: | A synthetic peptide of human MMP9 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 4318 |
Swiss Prot: | P14780 |
Synonyms: | CLG4B, GELB, MMP-9 |
Purification: | Affinity purification |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7 and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4). MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5). |
Caculated MW: | 78 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:500-1:2000 IHC 1:50-1:200 ICC 1:50-1:200 |
Reacitivity: | Human, Mouse, Rat |