ARP50943-01 [Polyclonal Antibody]
FOXP3 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A recombinant protein of human FOXP3
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   50943
Swiss Prot:   Q9BZS1
Synonyms:   AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain. The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 to FoxP4, which are broadly expressed and play important roles in organ development, immune response, and cancer pathogenesis. The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region, and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors. FoxP3 is crucial for the development of T cells with regulatory properties (Treg). Mutations in FoxP3 are associated with immunodeficiency polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX), while overexpression in mice causes severe immunodeficiency. In addition, FoxP3 functions as a tumor suppressor in several types of cancer.
Caculated MW:   47 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:2000
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information