ARP6624-11 [Polyclonal Antibody]
FSCN1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A recombinant protein corresponding to amino acids of human FSCN1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   6624
Swiss Prot:   Q16658
Synonyms:   FLJ38511, SNL, p55
Purification:   Affinity purification
Storage:   Store at 4°C. For long term storage store at -20°C in PBS (0.05% BSA, 0.05% sodium azide). Avoid freeze/thaw cycles.
Background:   Fascin is a monomeric, globular protein that plays a central role in regulating the structure and function of the cortical actin cytoskeleton (1). Fascin promotes cross-linkage of parallel actin filaments during the formation of cell protrusions (lamellipodia and filopodia), and therefore plays an important role in regulating cell migration (2). It has been reported that fascin may also regulate filopodia formation by a mechanism independent of its actin-bundling functions (3), though less is known about this mechanism of action. Research studies have shown that increased fascin expression is associated with increased motility and invasiveness of neoplastic cells, including breast, colon, prostate, and esophageal squamous cell carcinomas (4-6). Fascin binds to the armadillo-repeat domain of β-catenin in vitro and in vivo, and has been shown to co-localize with β-catenin and cadherins at the leading edge of migratory cells (7).
Caculated MW:   54 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:250-1:500
IHC 1:200-1:500
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information