ARP2068-01 [Polyclonal Antibody]
ERCC2 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IP
Immunogen Range:   A fusion protein of human ERCC2
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   2068
Swiss Prot:   P18074
Synonyms:   COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   XPB and XPD are ATPase/helicase subunits of the TFIIH complex that are involved in nucleotide excision repair (NER) to remove lesions and photoproducts generated by UV light. XPB and XPD are 3’-5’ and 5’-3’ DNA helicases, respectively, that play a role in opening of the DNA damage site to facilitate repair. XPB and XPD both play an important role in maintaining genomic stability, and researchers have linked mutations of these proteins to Xeroderma Pigmentosum (XP) and Trichothiodystrophy (TTD). XP patients have abnormalities in skin pigmentation and are highly susceptible to skin cancers, while TTD patients exhibit symptoms such as brittle hair, neurological abnormalities, and mild photosensitivity. In addition to their role in NER, XPB and XPD are involved in transcription initiation as part of the TFIIH core complex. The helicase activity of XPB unwinds DNA around the transcription start site to facilitate RNA polymerase II promoter clearance and initiation of transcription. XPD plays a structural role linking core TFIIH components with the cdk-activating kinase (CAK) complex that phosphorylates the C-terminus of the largest subunit of RNA polymerase II, leading to transcription initiation.
Caculated MW:   87 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
IHC 1:50-1:100
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information