ARP51176-01 [Polyclonal Antibody]
LEF1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   IHC
Immunogen Range:   A recombinant protein of human LEF1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   51176
Swiss Prot:   Q9UJU2
Synonyms:   KFZp586H0919, TCF1ALPHA
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Lymphoid enhancer-binding factor 1(LEF1) belongs to a family of regulatory protein share homology with high mobility group protein-1, and it's a nuclear protein exprssed in pre-B and T cells. LEF1 has a role in the Wnt signaling pathway and hair cell differentiation and follicle morphogenesis. Together with CTNNB1 and EP300, LEF1 activates transcription of target genes. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells
Caculated MW:   37 kDa
Observed MW:   Refer to Figures
Applications:   IHC 1:50-1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information