ARP3655-01 [Polyclonal Antibody]
ITGA6 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   A synthetic peptide of human ITGA6
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   3655
Swiss Prot:   P23229
Synonyms:   CD49f, VLA-6, ITGA6B
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2).Integrin α6 is a 120 kDa protein with two splice variants, integrin α6, 6A and 6B (3), which function as receptors for laminins on the basal membrane to mediate cellular adhesion events (4-6). α6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow.
Caculated MW:   127 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
IHC 1:50-1:100
IF 1:20-1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information