
| Species: | Rabbit |
| Applications: | WB IF FC |
| Immunogen Range: | A synthetic peptide of human NBN |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 4683 |
| Swiss Prot: | O60934 |
| Synonyms: | ATV, NBS, P95, NBS1, AT-V1, AT-V2 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
| Caculated MW: | 62 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:1000 IF 1:20-1:50 FC 1:20-1:50 |
| Reacitivity: | Human |