ARP558-01
[Polyclonal Antibody]
AXL Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IP |
| Immunogen Range: | A fusion protein of human AXL |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 558 |
| Swiss Prot: | P30530 |
| Synonyms: | AXL, JTK11, UFO |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | Axl, Sky and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4). |
| Caculated MW: | 98 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:1000 |
| Reacitivity: | Human, Mouse, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
