ARP2034-01 [Polyclonal Antibody]
EPAS1 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB FC
Immunogen Range:   A synthetic peptide of human HIF2A
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   2034
Swiss Prot:   Q99814
Synonyms:   EPAS1, BHLHE73, HIF2A, MOP2, PASD2
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Hypoxia-inducible factor (HIF) is essential for the cellular response to hypoxia (1,2). Under normoxia conditions, the α subunit of HIF is ubiquitinated by von Hippel-Lindau (VHL) protein and is degraded in the ubiquitin/proteasome pathway (1,2). Hypoxia inhibits the degradation of the α subunit, which leads to its stabilization (1,2). HIF, in turn, regulates the transcription of a variety of genes that respond to hypoxia conditions (1,2). There are several isoforms of the HIF α subunit (2). Studies have found that HIF-1α and HIF-2α expression is increased in some human cancers (2). HIF-1α has both pro- and anti-proliferative activities, whereas HIF-2α does not possess anti-proliferative activity (2). Therefore, HIF-2α likely plays an important role in tumorigenesis (2,3).
Caculated MW:   96 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:200-1:500
FC 1:20-1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information