ARP4088-01
[Polyclonal Antibody]
SMAD3 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IHC IP ICC |
| Immunogen Range: | A synthetic peptide of human SMAD3 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 4088 |
| Swiss Prot: | P84022 |
| Synonyms: | HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | Smad proteins belong to a group of intracellular signal transducers and downstream effectors of TGF-β/BMP Signaling. The family consists of nine members that are highly conserved in the N- and C-terminal regions. Smad3 is a key component in intracellular signaling of transforming growth factor beta (TGF-β), an inhibitor for tumor cell proliferation. Smad3 is activated by activin/TGF-β receptors, which form a heteromeric complex with Smad4, translocating to the nucleus and regulating the expression of TGF- β target genes. Interaction of Smad3 with Akt, can initiate TGF- β induced apoptosis and cell cycle arrest. Smad3 expression may be critical in tumor suppression in early stages of gastric carcinogenesis. |
| Caculated MW: | 58 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:1000 IHC 1:50-1:200 ICC 1:50-1:200 |
| Reacitivity: | Human, Mouse, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
