ARP5321-01
[Polyclonal Antibody]
PLA2G4A Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IHC IF FC |
| Immunogen Range: | A synthetic peptide of human cPLA2 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 5321 |
| Swiss Prot: | P47712 |
| Synonyms: | Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA, Lysophospholipase, PLA2G4, CPLA2, PLA2G4A |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | Cytosolic phospholipase A2 (cPLA2) is a ubiquitously distributed enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerolipids to produce lysophospholipids and release arachidonic acid (1). cPLA2 has been implicated in diverse cellular responses such as mitogenesis, differentiation, inflammation and cytotoxicity (1). Calcium binding to the amino-terminal CalB domain of cPLA2 promotes the translocation of cPLA2 from cytosol to membrane, where cPLA2 cleaves arachidonic acid from natural membrane (2). Phosphorylation of cPLA2 by MAPK (p42/44 and p38) at Ser505 (3,4) and Ser727 (5) stimulates its catalytic activity. |
| Caculated MW: | 85 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:200-1:500 IHC 1:50-1:100 IF 1:20-1:50 FC 1:20-1:50 |
| Reacitivity: | Human |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
