ARP3315-01 [Polyclonal Antibody]
HSPB1 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   WB IF
Immunogen Range:   A recombinant protein of human HSPB1
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   3315
Swiss Prot:   P04792
Synonyms:   HSPB1,CMT2F,DKFZp586P1322,HMN2B,HS.76067,HSP27,HSP28,Hsp25,SRP27
Purification:   Affinity purification
Storage:   Store at -20oC (regular) or -80oC (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background:   Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small heat shock proteins, HSPB1 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the expression level of HSPB1 increases several-fold to confer cellular resistance to the adverse environmental change. HSPB1 is phosphorylated at Ser15, Ser78 and Ser82 by MAPKAP kinase 2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSPB1 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSPB1 modulates actin polymerization and reorganization (5,6).
Caculated MW:   27kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500 - 1:2000
IF 1:20 - 1:100
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information