ARP4627-01 [Polyclonal Antibody]
MYH9 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IF
Immunogen Range:   A fusion protein of human MYH9
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   4627
Swiss Prot:   P35579
Synonyms:   DFNA17, EPSTS, FTNS, MGC104539, MHA, NMHC-II-A, NMMHCA, Myosin Iia
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Nonmuscle myosin is an actin-based motor protein essential to cell motility, cell division, migration, adhesion, and polarity. The holoenzyme consists of two identical heavy chains and two sets of light chains. The light chains (MLCs) regulate myosin II activity and stability. The heavy chains (NMHCs) are encoded by three genes, MYH9, MYH10, and MYH14, which generate three different nonmuscle myosin II isoforms, IIa, IIb, and IIc, respectively (reviewed in 1). While all three isoforms perform the same enzymatic tasks, binding to and contracting actin filaments coupled to ATP hydrolysis, their cellular functions do not appear to be redundant and they have different subcellular distributions (2-5). The carboxy-terminal tail domain of myosin II is important in isoform-specific subcellular localization (6). Phosphorylation of myosin IIa at Ser1943 contributes to the regulation of breast cancer cell migration (7).
Caculated MW:   227 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:500-1:1000
IHC 1:50-1:100
IF 1:20-1:50
Reacitivity:   Human, Mouse, Rat, Zebrafish
For research use only. Not intended for diagnostic or therapeutic use!
Additional information