ARP7014-01
[Polyclonal Antibody]
TERF2 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB |
| Immunogen Range: | A recombinant protein of human TERF2 |
| Clonality: | Polyclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 7014 |
| Swiss Prot: | Q15554 |
| Synonyms: | TRF2, TRBF2 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | Telomeres, the linear ends of chromosomes, are organized into T-loops to prevent them from being recognized by the cell as DNA double stranded breaks (DSBs) (1). The telomeric repeat binding factor proteins Trf1 and Trf2 bind to double-stranded telomeres to allow formation of T-loops (2). A large number of proteins involved in the DNA damage response are found physically associated with Trf2 within telomeres (3). Interestingly, Trf2 can transiently localize to DNA damage-induced DSBs, but overexpression of Trf2 prevents ATM-dependent signaling (4). Phosphorylation of Trf2 at Ser323 has been reported in vivo, but no upstream kinase or role has been established for this phosphorylation site (5). |
| Caculated MW: | 56 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:500-1:2000 |
| Reacitivity: | Human, Mouse |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information
