YMM02064-01 [Monoclonal Antibody]
Metronidazole(1C2) Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   IHC IF
Immunogen Range:   KLH conjugated with Metronidazole
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:  
Swiss Prot:  
Synonyms:   2-Methyl-5-nitroimidazole-1-ethanol
Purification:   Purified by Protein G.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole is an antibiotic, amebicide, and antiprotozoal.Metronidazole, taken up by diffusion, is selectively absorbed by anaerobic bacteria and sensitive protozoa. Once taken up by anaerobes, it is non-enzymatically reduced by reacting with reduced ferredoxin, which is generated by pyruvate oxido-reductase. Many of the reduced nitroso intermediates will form sulfinamides and thioether linkages with cysteine-bearing enzymes, thereby deactivating these critical enzymes. As many as 150 separate enzymes are affected.In addition or alternatively, the metronidazole metabolites are taken up into bacterial DNA, and form unstable molecules. This function only occurs when metronidazole is partially reduced, and because this reduction usually happens only in anaerobic cells, it has relatively little effect upon human cells or aerobic bacteria.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Others (Metronidazole)
For research use only. Not intended for diagnostic or therapeutic use!
Additional information