YMM02011-01 [Monoclonal Antibody]
PCNA(1C11) Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB IHC IF
Immunogen Range:   KLH conjugated synthetic peptide derived from human PCNA
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   5111
Swiss Prot:   P12004
Synonyms:   ATLD2, Proliferating cell nuclear antigen, PCNA, Cyclin
Purification:   Purified by Protein G.
Storage:   Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Background:   Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Reacitivity:   Human, Rat, Rabbit
For research use only. Not intended for diagnostic or therapeutic use!
Additional information